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MultiGroupSequential - Group-Sequential Procedures with Multiple Endpoints

Provides various testing procedures for group-sequential trials with multiple endpoints. Two sets of procedures are provided.

Last updated

openjdk

3.00 score 1 scripts 169 downloads

PWEALL - Design and Monitoring of Survival Trials Accounting for Complex Situations

Calculates various functions needed for design and monitoring survival trials accounting for complex situations such as delayed treatment effect, treatment crossover, non-uniform accrual, and different censoring distributions between groups. The event time distribution is assumed to be piecewise exponential (PWE) distribution and the entry time is assumed to be piecewise uniform distribution. As compared with Version 1.2.1, two more types of hybrid crossover are added. A bug is corrected in the function "pwecx" that calculates the crossover-adjusted survival, distribution, density, hazard and cumulative hazard functions. Also, to generate the crossover-adjusted event time random variable, a more efficient algorithm is used and the output includes crossover indicators.

Last updated

fortran

2.43 score 2 dependents 45 scripts 362 downloads

WLreg - Regression Analysis Based on Win Loss Endpoints

Use various regression models for the analysis of win loss endpoints adjusting for non-binary and multivariate covariates.

Last updated

fortran

1.00 score 6 scripts 153 downloads

NBDesign - Design and Monitoring of Clinical Trials with Negative Binomial Endpoint

Calculate various functions needed for design and monitoring clinical trials with negative binomial endpoint with variable follow-up. This version has a few changes compared to the previous version 1.0.0, including (1) correct a typo in Type 1 censoring, mtbnull=bnull and (2) restructure the code to account for shape parameter equal to zero, i.e. Poisson scenario.

Last updated

1.00 score 8 scripts 188 downloads